To minimize treatment interruptions due to adverse reactions, subsequent Phase III clinical trials may adopt a more gradual dose-escalation strategy to reduce the incidence and severity of gastrointestinal discomfort and other adverse events, thereby enhancing patient tolerance and adherence to the medication
Janaszak-Jasiecka A, Siekierzycka A, Bartoszewska S, Serocki M, Dobrucki LW, Collawn JF, Kalinowski L, Bartoszewski R (2018) eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells
Hepatology 80 (6), 14241440
doi: 10.1021/acschemneuro.6b00056 3 AlexopoulosP.SorgC.FrschlerA.GrimmerT.SkokouM.WohlschlgerA.et al
Nature Genetics
Alterations in growth plate development in CartIR / mice / To determine the importance of insulin signaling on growth plate development in vivo , we generated mice deficient in IR in chondrocytes as described in the section on Materials and methods